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Nutrients that Influence Bone Health
Bone is largely made of calcium, so adequate calcium intake is important, especially for slowing bone loss associated with aging.
Numerous controlled trials have found that calcium supplementation (usually in dosages of 800-1,500 mg per day), either alone or in combination with vitamin D, slowed the rate of age-related bone loss, reduced the incidence of fractures.
Because calcium may interfere with the absorption of other minerals that contribute to bone health (such as magnesium, zinc, manganese, and silicon), calcium should be administered as a component of a multimineral preparation, rather than by itself.
There is little evidence that any one form of supplemental calcium is preferable to others. Although calcium carbonate taken on an empty stomach is poorly absorbed by people with hypochlorhydria, calcium carbonate taken with food appears to be well absorbed regardless of gastric acid secretory capacity.
Vitamin D enhances calcium absorption and promotes bone mineralization. In randomized controlled trials in postmenopausal women, 800 IU per day of supplemental vitamin D decreased the incidence of fractures, whereas 400 IU per day was ineffective.
As a cofactor for alkaline phosphatase, magnesium plays a role in bone mineralization.
Low or suboptimal magnesium status is common in women with osteoporosis. In an uncontrolled trial, supplementation with 250-750 mg per day of magnesium for 1 to 2 years resulted in an increase in bone mineral density in 71% of 31 postmenopausal women.
Vitamin K is required for the synthesis of osteocalcin, a protein matrix that binds calcium ions in the process of bone mineralization.
Numerous controlled trials have found that administration of menaquinone-4 (MK-4; a type of vitamin K2) at a dosage of 45 mg per day slowed bone loss and reduced the incidence of fractures in postmenopausal women or elderly individuals.
Strontium is a trace mineral present in small amounts in the diet (about 2-3 mg per day). Strontium stimulates bone formation, inhibits bone resorption, and increases bone mineral density.
In double-blind trials, strontium supplementation (170-680 mg per day) significantly increased bone mineral density and decreased fracture incidence in postmenopausal women. Preliminary evidence suggests that 170 mg per day is at least as effective as 680 mg per day for fracture prevention, which raises the possibility that even lower dosages would be effective.
What is Calcium?
Calcium is the essential element for bone, and also an important messenger in cell function and neural signaling. Without sufficient Calcium in your body, your bone will weaken, then some neural functions and muscle functions may be affected, causing serious health problems.
What is Glucosamine?
Glucosamine is an amino sugar produced by the body. It plays an important role in the production, maintenance, and replenishment of cartilage - an essential connective tissue in the joints that prevents the bones from grinding together.
What is MSM?
MSM (Methylsulfonylmethane) is an organic sulfur-containing compound that occurs naturally in a variety of fruits, vegetables, grains and in animals, including humans in at least trace amounts. Because MSM is a source of sulfur, it is essential for the formation of connective tissue. MSM has been studied and is often used for easing joint discomfort. In a 2004 clinical study on MSM, the authors conclude that the combination of MSM with glucosamine provides better and more rapid improvement in joint health. Adding Chondroitin (another major component found in TripleFlex) to the mix, however, does not significantly increase the health benefits of Glucosamine and MSM.
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