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Glucosamine + MSM Forte 60 Capsules

Glucosamine + MSM Forte 60 Capsules
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Glucosamine + MSM Forte 60 Capsules

Health Function: Joint health
Manufacturer: Douglas Laboratories
Product Code: DGL83909-60X
Your Price: $25.90

Also available:

GlucosMSMFort120cs Glucosamine + MSM Forte 120 Capsules $44.90
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GlucosMSMFort250cs Glucosamine + MSM Forte 250 Capsules $80.50
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Glucosamine + MSM(R) Forte(TM) capsules provided by Douglas Laboratories contain 500 mg of pure glucosamine sulfate and 250 mg of methylsulfonylmethane (MSM(R)). Ascorbic acid, proanthocyanidins, and bromelain are also included to provide additional aid in maintaining the health of aging joints.

Each Capsule Contains:

Vitamin C (Ascorbic Acid)............................50 mg
Glucosamine Sulfate....................................500 mg
Methylsulfonylmethane (MSM(R)) ...............250 mg
Proanthocyanidins (red wine) ........................10 mg
Bromelain ......................................................10 mg

Who May Use

Glucosamine + MSM(R) Forte(TM) capsules may be a useful nutritional adjunct for individuals who wish to support the structure and function of the body's connective tissues, such as cartilage, bone, tendons, ligaments, and skin.

Suggested Usage

One capsule per day or as directed by a physician.

FUNCTIONS

Glucosamine is a naturally occurring amino sugar found in glycosoaminoglycans, integral components of the proteoglycans found in joint cartilage. Proteoglycans are large carbohydrate rich structures that provide resiliency, load distribution, shockabsorbing, compressive and lubricating properties to joints and connective tissues. The availability of glucosamine is an integral part of the synthesis of glycosaminoglycans and proteoglycans that are necessary during the constant remodeling that aging cartilage undergoes. Thus, the maintenance of healthy aging cartilage may be improved with enhanced deposition of glycosaminoglycans and proteoglycans.

Dietary glucosamine serves as an immediate precursor for glycosaminoglycan synthesis, and also stimulates incorporation of other precursors into the connective tissue matrix. Bioavailability of oral glucosamine sulfate is excellent. It is absorbed intact, and utilized very quickly by all tissues, including connective tissues. Glucosamine sulfate is more efficiently used for connective tissue metabolism than other glucosamine sources, such as cartilage extracts or chondroitin sulfate. In summary, glucosamine sulfate is a well recognized, highly effective source of glucosamine for glycosaminoglycan and proteoglycan synthesis in all connective tissues, such as cartilage, ligaments, tendons, skin, and bone.

MSM(R), a derivative of DMSO, is a naturally occurring compound of biologically available sulfur, an indispensable element in human nutrition. As part of the amino acids methionine and cysteine, sulfur is required for the structural integrity and function of almost every protein in the body, as well as the glycosaminoglycans of cartilage and other connective tissue. Dietary MSM(R) serves as a versatile donor of metabolically active sulfur for the synthesis of numerous organosulfur compounds and proteins in the body. As such, MSM(R) helps maintain normal immune response, lung function, connective tissue metabolism, and muscle contraction. MSM(R) occurs naturally in a variety of foods, such as fruits, vegetables, cereal grains, milk, and fish. However, MSM(R) is volatile and easily lost during cooking. MSM(R) is very well absorbed by the intestinal tract and rapidly distributed within the body. Bromelain, a protease from the pineapple plant, reduces the production of proinflammatory prostaglandins by modulating the arachidonate cascade. Its ability to modulate the body¡¯s normal inflammatory processes may reduce the discomfort associated with aging joints.

Proanthocyanidins, such as those found in red wine, are natural polyphenolic bioflavonoids that are widespread in nature and highly regarded for their strong antioxidant properties, as well as their functions in supporting the body¡¯s connective tissues. They have been shown to bind with collagen fibers, thereby protecting from premature degradation. This helps maintain the natural elasticity of collagen in skin, joints, arteries, capillaries, and other connective tissues.

Although vitamin C has numerous biological functions, foremost, it is essential for the synthesis of collagen and glycosaminoglycan which are the building materials of all connective tissues, such as joint cartilage, tendons, blood vessels, skin, and bone. Ascorbic acid (vitamin C) is the required coenzyme for two groups of enzymes that catalyze the cross linking of collagen fibers -lysyl hydroxylases and prolyl hydroxylases. Consequently, vitamin C is essential for the normal structure and function of connective tissue.

Side Effects

None reported.

Storage

Store in a cool, dry place, away from direct light. Keep out of reach of children.

REFERENCE

  1. Anonymous. [Gonarthrosis--current aspects of therapy with glucosamine sulfate (dona200-S)]. Fortschr Med Suppl 1998;183:1-12.
  2. D'Ambrosio E, Casa B, Bompani R, Scali G, Scali M. Glucosamine sulphate: a controlled clinical investigation in arthrosis. Pharmatherapeutica 1981;2:504-8.
  3. Giordano N, Nardi P, Senesi M, Palumbo F, Battisti E, Gonnelli S, Franci B, Campagna MS, Gennari C. [The efficacy and safety of glucosamine sulfate in the treatment of gonarthritis]. Clin Ter 1996;147:99-105.
  4. Gottlieb MS. Conservative management of spinal osteoarthritis with glucosamine sulfate and chiropractic treatment. J Manipulative Physiol Ther 1997;20:400-14.
  5. Kelly GS. The role of glucosamine sulfate and chondroitin sulfates in the treatment of degenerative joint disease. Altern Med Rev 1998;3:27-39.
  6. Leffler CT, Philippi AF, Leffler SG, Mosure JC, Kim PD. Glucosamine, chondroitin, and manganese ascorbate for degenerative joint disease of the knee or low back: a randomized, double-blind, placebo-controlled pilot study. Mil Med 1999;164:85-91.
  7. Lopes Vaz A. Double-blind clinical evaluation of the relative efficacy of ibuprofen and glucosamine sulphate in the management of osteoarthrosis of the knee in out-patients. Curr Med Res Opin 1982;8:145-9.
  8. Lotz-Winter H. On the pharmacology of bromelain: an update with special regard to animal studies on dose-dependent effects. Planta Med 1990;56:249-53.
  9. Masson M. [Bromelain in blunt injuries of the locomotor system. A study of observed applications in general practice]. Fortschr Med 1995;113:303-6.
  10. McCarty MF. The neglect of glucosamine as a treatment for osteoarthritis--a personal perspective. Med Hypotheses 1994;42:323-7.
  11. McCarty MF. Enhanced synovial production of hyaluronic acid may explain rapid clinical response to high-dose glucosamine in osteoarthritis. Med Hypotheses 1998;50:507-10.
  12. Murav'ev Iu V, Venikova MS, Pleskovskaia GN, Riazantseva TA, Sigidin Ia A. [Effect of dimethyl sulfoxide and dimethyl sulfone on a destructive process in the joints of mice with spontaneous arthritis]. Patol Fiziol Eksp Ter 1991;37-9.
  13. Pujalte JM, Llavore EP, Ylescupidez FR. Double-blind clinical evaluation of oral glucosamine sulphate in the basic treatment of osteoarthrosis. Curr Med Res Opin 1980;7:110-14.
  14. Qiu GX, Gao SN, Giacovelli G, Rovati L, Setnikar I. Efficacy and safety of glucosamine sulfate versus ibuprofen in patients with knee osteoarthritis. Arzneimittelforschung 1998;48:469-74.
  15. Richmond VL. Incorporation of methylsulfonylmethane sulfur into guinea pig serum proteins. Life Sci 1986;39:263-8.
  16. Rovati LC. Clinical research in osteoarthritis: design and results of shortterm and long-term trials with disease-modifying drugs. Int J Tissue React 1992;14:243-51.
  17. Russell AL. Glucosamine in osteoarthritis and gastrointestinal disorders: an exemplar of the need for a paradigm shift. Med Hypotheses 1998;51:347-9.
  18. Setnikar I. Antireactive properties of "chondroprotective" drugs. Int J Tissue React 1992;14:253-61.
  19. Setnikar I, Cereda R, Pacini MA, Revel L. Antireactive properties of glucosamine sulfate. Arzneimittelforschung 1991;41:157-61. Setnikar I, Pacini MA, Revel L. Antiarthritic effects of glucosamine sulfate studied in animal models. Arzneimittelforschung 1991;41:542-5.
  20. Shankland WE, 2nd. The effects of glucosamine and chondroitin sulfate on osteoarthritis of the TMJ: a preliminary report of 50 patients. Cranio 1998;16:230-5.
  21. Tapadinhas MJ, Rivera IC, Bignamini AA. Oral glucosamine sulphate in the management of arthrosis: report on a multi-centre open investigation in Portugal. Pharmatherapeutica 1982;3:157-68.
  22. Taussig SJ, Batkin S. Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update. J Ethnopharmacol 1988;22:191-203.

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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